Holistic process development to mitigate proteolysis of a subunit rotavirus vaccine candidate produced in Pichia pastoris by means of an acid pH pulse during fed‐batch fermentation

To meet the challenges of global health, vaccine design and development must be reconsidered to achieve cost of goods as low as 15¢ per dose. A new recombinant protein‐based rotavirus vaccine candidate derived from non‐replicative viral subunits fused to a P2 tetanus toxoid CD4(+) T cell epitope is...

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Bibliografiske detaljer
Udgivet i:Biotechnol Prog
Main Authors: Velez‐Suberbie, M. Lourdes, Morris, Stephen A., Kaur, Kawaljit, Hickey, John M., Joshi, Sangeeta B., Volkin, David B., Bracewell, Daniel G., Mukhopadhyay, Tarit K.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley & Sons, Inc. 2020
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RESEARCH ARTICLES
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7317458/
https://ncbi.nlm.nih.gov/pubmed/31960616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/btpr.2966
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