Amylin and beta amyloid proteins interact to form amorphous heterocomplexes with enhanced toxicity in neuronal cells

Human pancreatic islet amyloid polypeptide (hIAPP) and beta amyloid (Aβ) can accumulate in Type 2 diabetes (T2D) and Alzheimer’s disease (AD) brains and evidence suggests that interaction between the two amyloidogenic proteins can lead to the formation of heterocomplex aggregates. However, the struc...

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Publicado en:Sci Rep
Main Authors: Bharadwaj, Prashant, Solomon, Tanya, Sahoo, Bikash R., Ignasiak, Katarzyna, Gaskin, Scott, Rowles, Joanne, Verdile, Giuseppe, Howard, Mark J., Bond, Charles S., Ramamoorthy, Ayyalusamy, Martins, Ralph N., Newsholme, Philip
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316712/
https://ncbi.nlm.nih.gov/pubmed/32587390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66602-9
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