SETD2 deficiency accelerates MDS-associated leukemogenesis via S100a9 in NHD13 mice and predicts poor prognosis in MDS

SETD2, the histone H3 lysine 36 methyltransferase, previously identified by us, plays an important role in the pathogenesis of hematologic malignancies, but its role in myelodysplastic syndromes (MDSs) has been unclear. In this study, low expression of SETD2 correlated with shortened survival in pat...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Chen, Bing-Yi, Song, Junhong, Hu, Cheng-Long, Chen, Shu-Bei, Zhang, Qunling, Xu, Chun-Hui, Wu, Ji-Chuan, Hou, Dan, Sun, Ming, Zhang, Yuan-Liang, Liu, Na, Yu, Peng-Cheng, Liu, Ping, Zong, Li-Juan, Zhang, Jia-Ying, Dai, Ruo-Fei, Lan, Fei, Huang, Qiu-Hua, Zhang, Su-Jiang, Nimer, Stephen D., Chen, Zhu, Chen, Sai-Juan, Sun, Xiao-Jian, Wang, Lan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316210/
https://ncbi.nlm.nih.gov/pubmed/32202636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019001963
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