setd2 knockout zebrafish is viable and fertile: differential and developmental stress-related requirements for Setd2 and histone H3K36 trimethylation in different vertebrate animals

Setd2 is the only enzyme that catalyzes histone H3 lysine 36 trimethylation (H3K36me3) on virtually all actively transcribed protein-coding genes, and this mechanism is evolutionarily conserved from yeast to human. Despite this widespread and conserved activity, Setd2 and H3K36me3 are dispensable fo...

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Udgivet i:Cell Discov
Main Authors: Liu, Dian-Jia, Zhang, Fan, Chen, Yi, Jin, Yi, Zhang, Yuan-Liang, Chen, Shu-Bei, Xie, Yin-Yin, Huang, Qiu-Hua, Zhao, Wei-Li, Wang, Lan, Xu, Peng-Fei, Chen, Zhu, Chen, Sai-Juan, Li, Bing, Zhang, Aijun, Sun, Xiao-Jian
Format: Artigo
Sprog:Inglês
Udgivet: Springer Singapore 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7573620/
https://ncbi.nlm.nih.gov/pubmed/33088589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-020-00203-8
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