Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling

HYPB is a human histone H3 lysine 36 (H3K36)–specific methyltransferase and acts as the ortholog of yeast Set2. This study explored the physiological function of mammalian HYPB using knockout mice. Homozygous disruption of Hypb impaired H3K36 trimethylation but not mono- or dimethylation, and result...

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Main Authors: Hu, Ming, Sun, Xiao-Jian, Zhang, Yuan-Liang, Kuang, Ying, Hu, Chao-Quan, Wu, Wei-Li, Shen, Shu-Hong, Du, Ting-Ting, Li, Hong, He, Fei, Xiao, Hua-Sheng, Wang, Zhu-Gang, Liu, Ting-Xi, Lu, He, Huang, Qiu-Hua, Chen, Sai-Juan, Chen, Zhu
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2010
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840328/
https://ncbi.nlm.nih.gov/pubmed/20133625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0915033107
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