Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling

HYPB is a human histone H3 lysine 36 (H3K36)–specific methyltransferase and acts as the ortholog of yeast Set2. This study explored the physiological function of mammalian HYPB using knockout mice. Homozygous disruption of Hypb impaired H3K36 trimethylation but not mono- or dimethylation, and result...

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Main Authors: Hu, Ming, Sun, Xiao-Jian, Zhang, Yuan-Liang, Kuang, Ying, Hu, Chao-Quan, Wu, Wei-Li, Shen, Shu-Hong, Du, Ting-Ting, Li, Hong, He, Fei, Xiao, Hua-Sheng, Wang, Zhu-Gang, Liu, Ting-Xi, Lu, He, Huang, Qiu-Hua, Chen, Sai-Juan, Chen, Zhu
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2010
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840328/
https://ncbi.nlm.nih.gov/pubmed/20133625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0915033107
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