SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability

Modulating chromatin through histone methylation orchestrates numerous cellular processes. SETD2-dependent trimethylation of histone H3K36 is associated with active transcription. Here, we define a role for H3K36 trimethylation in homologous recombination (HR) repair in human cells. We find that dep...

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Autors principals: Pfister, Sophia X., Ahrabi, Sara, Zalmas, Lykourgos-Panagiotis, Sarkar, Sovan, Aymard, François, Bachrati, Csanád Z., Helleday, Thomas, Legube, Gaëlle, La Thangue, Nicholas B., Porter, Andrew C.G., Humphrey, Timothy C.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074340/
https://ncbi.nlm.nih.gov/pubmed/24931610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.05.026
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