Metformin Protects From Rotenone–Induced Nigrostriatal Neuronal Death in Adult Mice by Activating AMPK-FOXO3 Signaling and Mitigation of Angiogenesis

Parkinson’s disease (PD) is a neurodegenerative disease that affects substantia nigra dopamine neurons. Many studies have documented the role of oxidative stress and angiogenesis in the pathogenesis of PD. Metformin (MTF) is an antidiabetic medication and AMP-activated protein kinase (AMPK) regulato...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: El-Ghaiesh, Sabah H., Bahr, Hoda I., Ibrahiem, Afaf T., Ghorab, Doaa, Alomar, Suliman Y., Farag, Noha E., Zaitone, Sawsan A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7314970/
https://ncbi.nlm.nih.gov/pubmed/32625061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2020.00084
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