Metformin Protects From Rotenone–Induced Nigrostriatal Neuronal Death in Adult Mice by Activating AMPK-FOXO3 Signaling and Mitigation of Angiogenesis

Parkinson’s disease (PD) is a neurodegenerative disease that affects substantia nigra dopamine neurons. Many studies have documented the role of oxidative stress and angiogenesis in the pathogenesis of PD. Metformin (MTF) is an antidiabetic medication and AMP-activated protein kinase (AMPK) regulato...

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Bibliografische gegevens
Gepubliceerd in:Front Mol Neurosci
Hoofdauteurs: El-Ghaiesh, Sabah H., Bahr, Hoda I., Ibrahiem, Afaf T., Ghorab, Doaa, Alomar, Suliman Y., Farag, Noha E., Zaitone, Sawsan A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2020
Onderwerpen:
Neuroscience
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7314970/
https://ncbi.nlm.nih.gov/pubmed/32625061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2020.00084
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