Metformin Prevents Nigrostriatal Dopamine Degeneration Independent of AMPK Activation in Dopamine Neurons

Metformin is a widely prescribed drug used to treat type-2 diabetes, although recent studies show it has wide ranging effects to treat other diseases. Animal and retrospective human studies indicate that Metformin treatment is neuroprotective in Parkinson’s Disease (PD), although the neuroprotective...

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Pubblicato in:PLoS One
Autori principali: Bayliss, Jacqueline A., Lemus, Moyra B., Santos, Vanessa V., Deo, Minh, Davies, Jeffrey S., Kemp, Bruce E., Elsworth, John D., Andrews, Zane B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965122/
https://ncbi.nlm.nih.gov/pubmed/27467571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159381
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