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Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria
The human non-canonical inflammasome controls caspase-4 activation and gasdermin-D-dependent pyroptosis in response to cytosolic bacterial lipopolysaccharide (LPS). Since LPS binds and oligomerizes caspase-4, the pathway is thought to proceed without dedicated LPS sensors or an activation platform....
Tallennettuna:
| Julkaisussa: | Nat Commun |
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| Päätekijät: | , , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Nature Publishing Group UK
2020
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7314798/ https://ncbi.nlm.nih.gov/pubmed/32581219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16889-z |
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