Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11

Caspase-4/5 in humans and caspase-11 in mice bind hexa-acylated lipid A, the lipid moeity of lipopolysaccharide (LPS), to induce the activation of non-canonical inflammasome. Pathogens such as Francisella novicida express an under-acylated lipid A and escape caspase-11 recognition in mice. Here, we...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Lagrange, Brice, Benaoudia, Sacha, Wallet, Pierre, Magnotti, Flora, Provost, Angelina, Michal, Fanny, Martin, Amandine, Di Lorenzo, Flaviana, Py, Bénédicte F., Molinaro, Antonio, Henry, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770465/
https://ncbi.nlm.nih.gov/pubmed/29339744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02682-y
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