Bacterial outer membrane vesicles mediate cytosolic localization of LPS and caspase-11 activation

Sensing of lipopolysaccharide (LPS) in the cytosol triggers caspase-11 activation and is central to host defense against Gram-negative bacterial infections and to the pathogenesis of sepsis. Most Gram-negative bacteria that activate caspase-11 however are not cytosolic and the mechanism by which LPS...

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Udgivet i:Cell
Main Authors: Vanaja, Sivapriya Kailasan, Russo, Ashley J., Behl, Bharat, Banerjee, Ishita, Yankova, Maya, Deshmukh, Sachin D., Rathinam, Vijay A.K.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874922/
https://ncbi.nlm.nih.gov/pubmed/27156449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.04.015
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