Gasdermin D restrains type I interferon response to cytosolic DNA by disrupting ionic homeostasis

Inflammasome-activated caspase-1 cleaves gasdermin D to unmask its pore forming activity, the predominant consequence of which is pyroptosis. Here, we report an additional biological role for gasdermin D in limiting cytosolic DNA surveillance. Cytosolic DNA is sensed by Aim2 and cyclic GMP-AMP synth...

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Gepubliceerd in:Immunity
Hoofdauteurs: Banerjee, Ishita, Behl, Bharat, Mendonca, Morena, Shrivastava, Gaurav, Russo, Ashley J., Menoret, Antoine, Ghosh, Arundhati, Vella, Anthony T., Vanaja, Sivapriya Kailasan, Sarkar, Saumendra N., Fitzgerald, Katherine A., Rathinam, Vijay A.K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6347470/
https://ncbi.nlm.nih.gov/pubmed/30170814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.07.006
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