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Guanylate-Binding Proteins (GBPs) convert cytosolic bacteria into caspase-4 signaling platforms
Bacterial lipopolysaccharide triggers human caspase-4 (murine caspase-11) to cleave gasdermin-D and induce pyroptotic cell death. How lipopolysaccharide sequestered in membranes of cytosol-invading bacteria activates caspases remains unknown. Here we show that in interferon-γ stimulated cells guanyl...
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| Publicado no: | Nat Immunol |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7381384/ https://ncbi.nlm.nih.gov/pubmed/32541830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-020-0697-2 |
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