Chronic intermittent tachypacing by an optogenetic approach induces arrhythmia vulnerability in human engineered heart tissue

AIMS: Chronic tachypacing is commonly used in animals to induce cardiac dysfunction and to study mechanisms of heart failure and arrhythmogenesis. Human induced pluripotent stem cells (hiPSC) may replace animal models to overcome species differences and ethical problems. Here, 3D engineered heart ti...

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Detalhes bibliográficos
Publicado no:Cardiovasc Res
Main Authors: Lemme, Marta, Braren, Ingke, Prondzynski, Maksymilian, Aksehirlioglu, Bülent, Ulmer, Bärbel M, Schulze, Mirja L, Ismaili, Djemail, Meyer, Christian, Hansen, Arne, Christ, Torsten, Lemoine, Marc D, Eschenhagen, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7314638/
https://ncbi.nlm.nih.gov/pubmed/31598634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvz245
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