Human iPSC-derived cardiomyocytes cultured in 3D engineered heart tissue show physiological upstroke velocity and sodium current density

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are a promising tool for drug testing and modelling genetic disorders. Abnormally low upstroke velocity is a current limitation. Here we investigated the use of 3D engineered heart tissue (EHT) as a culture method with greater res...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Lemoine, Marc D., Mannhardt, Ingra, Breckwoldt, Kaja, Prondzynski, Maksymilian, Flenner, Frederik, Ulmer, Bärbel, Hirt, Marc N., Neuber, Christiane, Horváth, András, Kloth, Benjamin, Reichenspurner, Hermann, Willems, Stephan, Hansen, Arne, Eschenhagen, Thomas, Christ, Torsten
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5511281/
https://ncbi.nlm.nih.gov/pubmed/28710467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05600-w
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