Blinded Contractility Analysis in hiPSC-Cardiomyocytes in Engineered Heart Tissue Format: Comparison With Human Atrial Trabeculae

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) may serve as a new assay for drug testing in a human context, but their validity particularly for the evaluation of inotropic drug effects remains unclear. In this blinded analysis, we compared the effects of 10 indicator compound...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Toxicol Sci
Prif Awduron: Mannhardt, Ingra, Eder, Alexandra, Dumotier, Berengere, Prondzynski, Maksymilian, Krämer, Elisabeth, Traebert, Martin, Söhren, Klaus-Dieter, Flenner, Frederik, Stathopoulou, Konstantina, Lemoine, Marc D., Carrier, Lucie, Christ, Torsten, Eschenhagen, Thomas, Hansen, Arne
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2017
Pynciau:
Cardiomyocyte Contractility in Engineered Heart Tissue
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837217/
https://ncbi.nlm.nih.gov/pubmed/28453742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfx081
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