Low Resting Membrane Potential and Low Inward Rectifier Potassium Currents Are Not Inherent Features of hiPSC-Derived Cardiomyocytes

Human induced pluripotent stem cell (hiPSC) cardiomyocytes (CMs) show less negative resting membrane potential (RMP), which is attributed to small inward rectifier currents (I(K1)). Here, I(K1) was measured in hiPSC-CMs (proprietary and commercial cell line) cultured as monolayer (ML) or 3D engineer...

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Gepubliceerd in:Stem Cell Reports
Hoofdauteurs: Horváth, András, Lemoine, Marc D., Löser, Alexandra, Mannhardt, Ingra, Flenner, Frederik, Uzun, Ahmet Umur, Neuber, Christiane, Breckwoldt, Kaja, Hansen, Arne, Girdauskas, Evaldas, Reichenspurner, Hermann, Willems, Stephan, Jost, Norbert, Wettwer, Erich, Eschenhagen, Thomas, Christ, Torsten
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5918194/
https://ncbi.nlm.nih.gov/pubmed/29429959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.01.012
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