Blinded Contractility Analysis in hiPSC-Cardiomyocytes in Engineered Heart Tissue Format: Comparison With Human Atrial Trabeculae

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) may serve as a new assay for drug testing in a human context, but their validity particularly for the evaluation of inotropic drug effects remains unclear. In this blinded analysis, we compared the effects of 10 indicator compound...

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Veröffentlicht in:Toxicol Sci
Hauptverfasser: Mannhardt, Ingra, Eder, Alexandra, Dumotier, Berengere, Prondzynski, Maksymilian, Krämer, Elisabeth, Traebert, Martin, Söhren, Klaus-Dieter, Flenner, Frederik, Stathopoulou, Konstantina, Lemoine, Marc D., Carrier, Lucie, Christ, Torsten, Eschenhagen, Thomas, Hansen, Arne
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
Schlagworte:
Cardiomyocyte Contractility in Engineered Heart Tissue
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837217/
https://ncbi.nlm.nih.gov/pubmed/28453742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfx081
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