Chronic intermittent tachypacing by an optogenetic approach induces arrhythmia vulnerability in human engineered heart tissue

AIMS: Chronic tachypacing is commonly used in animals to induce cardiac dysfunction and to study mechanisms of heart failure and arrhythmogenesis. Human induced pluripotent stem cells (hiPSC) may replace animal models to overcome species differences and ethical problems. Here, 3D engineered heart ti...

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Bibliografiska uppgifter
I publikationen:Cardiovasc Res
Huvudupphovsmän: Lemme, Marta, Braren, Ingke, Prondzynski, Maksymilian, Aksehirlioglu, Bülent, Ulmer, Bärbel M, Schulze, Mirja L, Ismaili, Djemail, Meyer, Christian, Hansen, Arne, Christ, Torsten, Lemoine, Marc D, Eschenhagen, Thomas
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2020
Ämnen:
Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7314638/
https://ncbi.nlm.nih.gov/pubmed/31598634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvz245
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