Regulation of I(Ca,L) and force by PDEs in human‐induced pluripotent stem cell‐derived cardiomyocytes

BACKGROUND AND PURPOSE: Phosphodiesterases (PDEs) are important regulators of β‐adrenoceptor signalling in the heart. While PDE4 is the most important isoform that regulates I(Ca,L) and force in rodent cardiomyocytes, the dominant isoform in adult human cardiomyocytes is PDE3. EXPERIMENTAL APPROACH:...

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Enregistré dans:
Détails bibliographiques
Publié dans:Br J Pharmacol
Auteurs principaux: Saleem, Umber, Ismaili, Djemail, Mannhardt, Ingra, Pinnschmidt, Hans, Schulze, Thomas, Christ, Torsten, Eschenhagen, Thomas, Hansen, Arne
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
Sujets:
Research Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7279982/
https://ncbi.nlm.nih.gov/pubmed/32092149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15032
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