Regulation of I(Ca,L) and force by PDEs in human‐induced pluripotent stem cell‐derived cardiomyocytes

BACKGROUND AND PURPOSE: Phosphodiesterases (PDEs) are important regulators of β‐adrenoceptor signalling in the heart. While PDE4 is the most important isoform that regulates I(Ca,L) and force in rodent cardiomyocytes, the dominant isoform in adult human cardiomyocytes is PDE3. EXPERIMENTAL APPROACH:...

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Опубликовано в: :Br J Pharmacol
Главные авторы: Saleem, Umber, Ismaili, Djemail, Mannhardt, Ingra, Pinnschmidt, Hans, Schulze, Thomas, Christ, Torsten, Eschenhagen, Thomas, Hansen, Arne
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2020
Предметы:
Research Papers
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7279982/
https://ncbi.nlm.nih.gov/pubmed/32092149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15032
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