Regulation of I(Ca,L) and force by PDEs in human‐induced pluripotent stem cell‐derived cardiomyocytes

BACKGROUND AND PURPOSE: Phosphodiesterases (PDEs) are important regulators of β‐adrenoceptor signalling in the heart. While PDE4 is the most important isoform that regulates I(Ca,L) and force in rodent cardiomyocytes, the dominant isoform in adult human cardiomyocytes is PDE3. EXPERIMENTAL APPROACH:...

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Dettagli Bibliografici
Pubblicato in:Br J Pharmacol
Autori principali: Saleem, Umber, Ismaili, Djemail, Mannhardt, Ingra, Pinnschmidt, Hans, Schulze, Thomas, Christ, Torsten, Eschenhagen, Thomas, Hansen, Arne
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7279982/
https://ncbi.nlm.nih.gov/pubmed/32092149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15032
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