Stress-responsive MTK1 SAPKKK serves as a redox sensor that mediates delayed and sustained activation of SAPKs by oxidative stress

Cells respond to oxidative stress by inducing intracellular signaling, including stress-activated p38 and JNK MAPK (SAPK) pathways, but the underlying mechanisms remain unclear. Here, we report that the MAP three kinase 1 (MTK1) SAPK kinase kinase (SAPKKK) functions as an oxidative-stress sensor tha...

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Detalles Bibliográficos
Publicado en:Sci Adv
Main Authors: Matsushita, Moe, Nakamura, Takanori, Moriizumi, Hisashi, Miki, Hiroaki, Takekawa, Mutsuhiro
Formato: Artigo
Idioma:Inglês
Publicado: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7314524/
https://ncbi.nlm.nih.gov/pubmed/32637591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay9778
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