Regulation of MTK1/MEKK4 Kinase Activity by Its N-Terminal Autoinhibitory Domain and GADD45 Binding

A variety of cellular stresses activate the stress-responsive mitogen-activated protein (MAP) kinases p38 and JNK. In this study, we studied the activation mechanism of a human MAP kinase kinase kinase, MTK1 (also known as MEKK4), which mediates activation of both p38 and JNK. MTK1 has an extensive...

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Detalhes bibliográficos
Main Authors: Mita, Hiroaki, Tsutsui, Junichiro, Takekawa, Mutsuhiro, Witten, Elizabeth A., Saito, Haruo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133894/
https://ncbi.nlm.nih.gov/pubmed/12052864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.13.4544-4555.2002
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