Regulation of MTK1/MEKK4 Kinase Activity by Its N-Terminal Autoinhibitory Domain and GADD45 Binding

A variety of cellular stresses activate the stress-responsive mitogen-activated protein (MAP) kinases p38 and JNK. In this study, we studied the activation mechanism of a human MAP kinase kinase kinase, MTK1 (also known as MEKK4), which mediates activation of both p38 and JNK. MTK1 has an extensive...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Mita, Hiroaki, Tsutsui, Junichiro, Takekawa, Mutsuhiro, Witten, Elizabeth A., Saito, Haruo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2002
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133894/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12052864/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.13.4544-4555.2002
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