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Activation of MTK1/MEKK4 by GADD45 through Induced N-C Dissociation and Dimerization-Mediated trans Autophosphorylation of the MTK1 Kinase Domain

The mitogen-activated protein kinase (MAPK) module, composed of a MAPK, a MAPK kinase (MAPKK), and a MAPKK kinase (MAPKKK), is a cellular signaling device that is conserved throughout the eukaryotic world. In mammalian cells, various extracellular stresses activate two major subfamilies of MAPKs, na...

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Detalles Bibliográficos
Main Authors: Miyake, Zenshi, Takekawa, Mutsuhiro, Ge, Qingyuan, Saito, Haruo
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899887/
https://ncbi.nlm.nih.gov/pubmed/17242196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01435-06
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