Widespread transcript shortening through alternative polyadenylation in secretory cell differentiation

Most eukaryotic genes produce alternative polyadenylation (APA) isoforms. Here we report that, unlike previously characterized cell lineages, differentiation of syncytiotrophoblast (SCT), a cell type critical for hormone production and secretion during pregnancy, elicits widespread transcript shorte...

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Vydáno v:Nat Commun
Hlavní autoři: Cheng, Larry C., Zheng, Dinghai, Baljinnyam, Erdene, Sun, Fangzheng, Ogami, Koichi, Yeung, Percy Luk, Hoque, Mainul, Lu, Chi-Wei, Manley, James L., Tian, Bin
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311474/
https://ncbi.nlm.nih.gov/pubmed/32576858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16959-2
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