RBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3′ UTRs

Polyadenylation of mRNA precursors is mediated by a large multisubunit protein complex. Here we show that RBBP6 (retinoblastoma-binding protein 6), identified initially as an Rb- and p53-binding protein, is a component of this complex and functions in 3′ processing in vitro and in vivo. RBBP6 associ...

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Autors principals: Di Giammartino, Dafne Campigli, Li, Wencheng, Ogami, Koichi, Yashinskie, Jossie J., Hoque, Mainul, Tian, Bin, Manley, James L.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2014
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201286/
https://ncbi.nlm.nih.gov/pubmed/25319826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.245787.114
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