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Transcriptional activity regulates alternative cleavage and polyadenylation

Genes containing multiple pre-mRNA cleavage and polyadenylation sites, or polyA sites, express mRNA isoforms with variable 3′ untranslated regions (UTRs). By systematic analysis of human and mouse transcriptomes, we found that short 3′UTR isoforms are relatively more abundant when genes are highly e...

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Main Authors: Ji, Zhe, Luo, Wenting, Li, Wencheng, Hoque, Mainul, Pan, Zhenhua, Zhao, Yun, Tian, Bin
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202805/
https://ncbi.nlm.nih.gov/pubmed/21952137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2011.69
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