Transcriptional activity regulates alternative cleavage and polyadenylation

Genes containing multiple pre-mRNA cleavage and polyadenylation sites, or polyA sites, express mRNA isoforms with variable 3′ untranslated regions (UTRs). By systematic analysis of human and mouse transcriptomes, we found that short 3′UTR isoforms are relatively more abundant when genes are highly e...

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Bibliographic Details
Main Authors: Ji, Zhe, Luo, Wenting, Li, Wencheng, Hoque, Mainul, Pan, Zhenhua, Zhao, Yun, Tian, Bin
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202805/
https://ncbi.nlm.nih.gov/pubmed/21952137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2011.69
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