Transcriptional activity regulates alternative cleavage and polyadenylation

Genes containing multiple pre-mRNA cleavage and polyadenylation sites, or polyA sites, express mRNA isoforms with variable 3′ untranslated regions (UTRs). By systematic analysis of human and mouse transcriptomes, we found that short 3′UTR isoforms are relatively more abundant when genes are highly e...

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Main Authors: Ji, Zhe, Luo, Wenting, Li, Wencheng, Hoque, Mainul, Pan, Zhenhua, Zhao, Yun, Tian, Bin
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202805/
https://ncbi.nlm.nih.gov/pubmed/21952137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2011.69
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