Systematic Profiling of Poly(A)+ Transcripts Modulated by Core 3’ End Processing and Splicing Factors Reveals Regulatory Rules of Alternative Cleavage and Polyadenylation

Alternative cleavage and polyadenylation (APA) results in mRNA isoforms containing different 3’ untranslated regions (3’UTRs) and/or coding sequences. How core cleavage/polyadenylation (C/P) factors regulate APA is not well understood. Using siRNA knockdown coupled with deep sequencing, we found tha...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:PLoS Genet
Autori principali: Li, Wencheng, You, Bei, Hoque, Mainul, Zheng, Dinghai, Luo, Wenting, Ji, Zhe, Park, Ji Yeon, Gunderson, Samuel I., Kalsotra, Auinash, Manley, James L., Tian, Bin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407891/
https://ncbi.nlm.nih.gov/pubmed/25906188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005166
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi