Systematic Profiling of Poly(A)+ Transcripts Modulated by Core 3’ End Processing and Splicing Factors Reveals Regulatory Rules of Alternative Cleavage and Polyadenylation

Alternative cleavage and polyadenylation (APA) results in mRNA isoforms containing different 3’ untranslated regions (3’UTRs) and/or coding sequences. How core cleavage/polyadenylation (C/P) factors regulate APA is not well understood. Using siRNA knockdown coupled with deep sequencing, we found tha...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Li, Wencheng, You, Bei, Hoque, Mainul, Zheng, Dinghai, Luo, Wenting, Ji, Zhe, Park, Ji Yeon, Gunderson, Samuel I., Kalsotra, Auinash, Manley, James L., Tian, Bin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407891/
https://ncbi.nlm.nih.gov/pubmed/25906188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005166
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