Systematic Profiling of Poly(A)+ Transcripts Modulated by Core 3’ End Processing and Splicing Factors Reveals Regulatory Rules of Alternative Cleavage and Polyadenylation

Alternative cleavage and polyadenylation (APA) results in mRNA isoforms containing different 3’ untranslated regions (3’UTRs) and/or coding sequences. How core cleavage/polyadenylation (C/P) factors regulate APA is not well understood. Using siRNA knockdown coupled with deep sequencing, we found tha...

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Bibliografiske detaljer
Udgivet i:PLoS Genet
Main Authors: Li, Wencheng, You, Bei, Hoque, Mainul, Zheng, Dinghai, Luo, Wenting, Ji, Zhe, Park, Ji Yeon, Gunderson, Samuel I., Kalsotra, Auinash, Manley, James L., Tian, Bin
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407891/
https://ncbi.nlm.nih.gov/pubmed/25906188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005166
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