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PARP1 REPRESSES PAP AND INHIBITS POLYADENYLATION DURING HEAT SHOCK
The 3′ ends of most eukaryotic mRNAs are produced by an endonucleolytic cleavage followed by synthesis of a poly(A) tail. Poly(A) polymerase (PAP), the enzyme that catalyzes the formation of the tail, is subject to tight regulation involving several post-translational modifications. Here we show tha...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3545032/ https://ncbi.nlm.nih.gov/pubmed/23219533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.11.005 |
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