Hemoglobin oxidation generates globin-derived peptides in atherosclerotic lesions and intraventricular hemorrhage of the brain, provoking endothelial dysfunction

The lysis of red blood cells was shown to occur in human ruptured atherosclerotic lesions and intraventricular hemorrhage (IVH) of the brain. Liberated cell-free hemoglobin was found to undergo oxidation in both pathologies. We hypothesize that hemoglobin-derived peptides are generated during hemogl...

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Dettagli Bibliografici
Pubblicato in:Lab Invest
Autori principali: Posta, Niké, Csősz, Éva, Oros, Melinda, Pethő, Dávid, Potor, László, Kalló, Gergő, Hendrik, Zoltán, Sikura, Katalin Éva, Méhes, Gábor, Tóth, Csaba, Posta, József, Balla, György, Balla, József
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group US 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311325/
https://ncbi.nlm.nih.gov/pubmed/32054994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41374-020-0403-x
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