Hemoglobin oxidation generates globin-derived peptides in atherosclerotic lesions and intraventricular hemorrhage of the brain, provoking endothelial dysfunction

The lysis of red blood cells was shown to occur in human ruptured atherosclerotic lesions and intraventricular hemorrhage (IVH) of the brain. Liberated cell-free hemoglobin was found to undergo oxidation in both pathologies. We hypothesize that hemoglobin-derived peptides are generated during hemogl...

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Vydáno v:Lab Invest
Hlavní autoři: Posta, Niké, Csősz, Éva, Oros, Melinda, Pethő, Dávid, Potor, László, Kalló, Gergő, Hendrik, Zoltán, Sikura, Katalin Éva, Méhes, Gábor, Tóth, Csaba, Posta, József, Balla, György, Balla, József
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group US 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311325/
https://ncbi.nlm.nih.gov/pubmed/32054994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41374-020-0403-x
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