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Hemoglobin oxidation generates globin-derived peptides in atherosclerotic lesions and intraventricular hemorrhage of the brain, provoking endothelial dysfunction

The lysis of red blood cells was shown to occur in human ruptured atherosclerotic lesions and intraventricular hemorrhage (IVH) of the brain. Liberated cell-free hemoglobin was found to undergo oxidation in both pathologies. We hypothesize that hemoglobin-derived peptides are generated during hemogl...

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Bibliografski detalji
Izdano u:Lab Invest
Glavni autori: Posta, Niké, Csősz, Éva, Oros, Melinda, Pethő, Dávid, Potor, László, Kalló, Gergő, Hendrik, Zoltán, Sikura, Katalin Éva, Méhes, Gábor, Tóth, Csaba, Posta, József, Balla, György, Balla, József
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group US 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311325/
https://ncbi.nlm.nih.gov/pubmed/32054994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41374-020-0403-x
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