Heme cytotoxicity is the consequence of endoplasmic reticulum stress in atherosclerotic plaque progression

Hemorrhage and hemolysis with subsequent heme release are implicated in many pathologies. Endothelial cells (ECs) encounter large amount of free heme after hemolysis and are at risk of damage from exogenous heme. Here we show that hemorrhage aggravates endoplasmic reticulum (ER) stress in human caro...

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Published in:Sci Rep
Main Authors: Pethő, Dávid, Hendrik, Zoltán, Nagy, Annamária, Beke, Lívia, Patsalos, Andreas, Nagy, László, Póliska, Szilárd, Méhes, Gábor, Tóth, Csaba, Potor, László, Eaton, John W., Jacob, Harry S., Balla, György, Balla, József, Gáll, Tamás
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8129109/
https://ncbi.nlm.nih.gov/pubmed/34001932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-89713-3
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