Heme cytotoxicity is the consequence of endoplasmic reticulum stress in atherosclerotic plaque progression

Hemorrhage and hemolysis with subsequent heme release are implicated in many pathologies. Endothelial cells (ECs) encounter large amount of free heme after hemolysis and are at risk of damage from exogenous heme. Here we show that hemorrhage aggravates endoplasmic reticulum (ER) stress in human caro...

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Publicado en:Sci Rep
Main Authors: Pethő, Dávid, Hendrik, Zoltán, Nagy, Annamária, Beke, Lívia, Patsalos, Andreas, Nagy, László, Póliska, Szilárd, Méhes, Gábor, Tóth, Csaba, Potor, László, Eaton, John W., Jacob, Harry S., Balla, György, Balla, József, Gáll, Tamás
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8129109/
https://ncbi.nlm.nih.gov/pubmed/34001932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-89713-3
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