Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation

RATIONALE: Small molecule inhibitors of the acetyl-histone binding protein BRD4 have been shown to block cardiac fibrosis in pre-clinical models of heart failure (HF). However, since the inhibitors target BRD4 ubiquitously, it is unclear whether this chromatin reader protein functions in cell type-s...

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Veröffentlicht in:Circ Res
Hauptverfasser: Stratton, Matthew S., Bagchi, Rushita A., Felisbino, Marina B., Hirsch, Rachel A., Smith, Harrison E., Riching, Andrew S., Enyart, Blake Y., Koch, Keith A., Cavasin, Maria A., Alexanian, Michael, Song, Kunhua, Qi, Jun, Lemieux, Madeleine E., Srivastava, Deepak, Lam, Maggie P.Y., Haldar, Saptarsi M., Lin, Charles Y., McKinsey, Timothy A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7310347/
https://ncbi.nlm.nih.gov/pubmed/31409188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.119.315125
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