Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation

RATIONALE: Small molecule inhibitors of the acetyl-histone binding protein BRD4 have been shown to block cardiac fibrosis in pre-clinical models of heart failure (HF). However, since the inhibitors target BRD4 ubiquitously, it is unclear whether this chromatin reader protein functions in cell type-s...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Circ Res
Egile Nagusiak: Stratton, Matthew S., Bagchi, Rushita A., Felisbino, Marina B., Hirsch, Rachel A., Smith, Harrison E., Riching, Andrew S., Enyart, Blake Y., Koch, Keith A., Cavasin, Maria A., Alexanian, Michael, Song, Kunhua, Qi, Jun, Lemieux, Madeleine E., Srivastava, Deepak, Lam, Maggie P.Y., Haldar, Saptarsi M., Lin, Charles Y., McKinsey, Timothy A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7310347/
https://ncbi.nlm.nih.gov/pubmed/31409188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.119.315125
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