Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation

RATIONALE: Small molecule inhibitors of the acetyl-histone binding protein BRD4 have been shown to block cardiac fibrosis in pre-clinical models of heart failure (HF). However, since the inhibitors target BRD4 ubiquitously, it is unclear whether this chromatin reader protein functions in cell type-s...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Circ Res
Main Authors: Stratton, Matthew S., Bagchi, Rushita A., Felisbino, Marina B., Hirsch, Rachel A., Smith, Harrison E., Riching, Andrew S., Enyart, Blake Y., Koch, Keith A., Cavasin, Maria A., Alexanian, Michael, Song, Kunhua, Qi, Jun, Lemieux, Madeleine E., Srivastava, Deepak, Lam, Maggie P.Y., Haldar, Saptarsi M., Lin, Charles Y., McKinsey, Timothy A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7310347/
https://ncbi.nlm.nih.gov/pubmed/31409188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.119.315125
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados