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Cryo-EM structure and dynamics of eukaryotic DNA polymerase δ holoenzyme

DNA polymerase δ (Polδ) plays pivotal roles in eukaryotic DNA replication and repair. Polδ is conserved from yeast to humans, and mutations in human Polδ have been implicated in various cancers. Saccharomyces cerevisiae Polδ consists of catalytic Pol3 and the regulatory Pol31 and Pol32 subunits. Her...

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Vydáno v:Nat Struct Mol Biol
Hlavní autoři: Jain, Rinku, Rice, William J., Malik, Radhika, Johnson, Robert E., Prakash, Louise, Prakash, Satya, Ubarretxena-Belandia, Iban, Aggarwal, Aneel K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7309520/
https://ncbi.nlm.nih.gov/pubmed/31582849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0305-z
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