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Structure and Mechanism of B-family DNA Polymerase ζ Specialized for Translesion DNA Synthesis
DNA polymerase ζ (Polζ) belongs to the same B-family as high-fidelity replicative polymerases, and yet is specialized for the extension reaction in translesion DNA synthesis (TLS). Despite its importance in TLS, the structure of Polζ is unknown. We present cryo-EM structures of S.cerevisiae Polζ hol...
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| Udgivet i: | Nat Struct Mol Biol |
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| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7554088/ https://ncbi.nlm.nih.gov/pubmed/32807989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0476-7 |
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