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Cryo-EM structure and dynamics of eukaryotic DNA polymerase δ holoenzyme
DNA polymerase δ (Polδ) plays pivotal roles in eukaryotic DNA replication and repair. Polδ is conserved from yeast to humans, and mutations in human Polδ have been implicated in various cancers. Saccharomyces cerevisiae Polδ consists of catalytic Pol3 and the regulatory Pol31 and Pol32 subunits. Her...
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| Publié dans: | Nat Struct Mol Biol |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7309520/ https://ncbi.nlm.nih.gov/pubmed/31582849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0305-z |
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