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Regulation of polymerase exchange between Polη and Polδ by monoubiquitination of PCNA and the movement of DNA polymerase holoenzyme

To ensure efficient and timely replication of genomic DNA, organisms in all three kingdoms of life possess specialized translesion DNA synthesis (TLS) polymerases (Pols) that tolerate various types of DNA lesions. It has been proposed that an exchange between the replicative DNA Pol and the TLS Pol...

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Detalhes bibliográficos
Main Authors: Zhuang, Zhihao, Johnson, Robert E., Haracska, Lajos, Prakash, Louise, Prakash, Satya, Benkovic, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291123/
https://ncbi.nlm.nih.gov/pubmed/18385374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801310105
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