Development of a 3Mut-Apex-Stabilized Envelope Trimer That Expands HIV-1 Neutralization Breadth When Used To Boost Fusion Peptide-Directed Vaccine-Elicited Responses

HIV-1 envelope (Env) trimers, stabilized in a prefusion-closed conformation, can elicit humoral responses capable of neutralizing HIV-1 strains closely matched in sequence to the immunizing strain. One strategy to increase elicited neutralization breadth involves vaccine priming of immune responses...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Chuang, Gwo-Yu, Lai, Yen-Ting, Boyington, Jeffrey C., Cheng, Cheng, Geng, Hui, Narpala, Sandeep, Rawi, Reda, Schmidt, Stephen D., Tsybovsky, Yaroslav, Verardi, Raffaello, Xu, Kai, Yang, Yongping, Zhang, Baoshan, Chambers, Michael, Changela, Anita, Corrigan, Angela R., Kong, Rui, Olia, Adam S., Ou, Li, Sarfo, Edward K., Wang, Shuishu, Wu, Winston, Doria-Rose, Nicole A., McDermott, Adrian B., Mascola, John R., Kwong, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2020
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7307166/
https://ncbi.nlm.nih.gov/pubmed/32295908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00074-20
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