Development of a 3Mut-Apex-Stabilized Envelope Trimer That Expands HIV-1 Neutralization Breadth When Used To Boost Fusion Peptide-Directed Vaccine-Elicited Responses

HIV-1 envelope (Env) trimers, stabilized in a prefusion-closed conformation, can elicit humoral responses capable of neutralizing HIV-1 strains closely matched in sequence to the immunizing strain. One strategy to increase elicited neutralization breadth involves vaccine priming of immune responses...

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發表在:J Virol
Main Authors: Chuang, Gwo-Yu, Lai, Yen-Ting, Boyington, Jeffrey C., Cheng, Cheng, Geng, Hui, Narpala, Sandeep, Rawi, Reda, Schmidt, Stephen D., Tsybovsky, Yaroslav, Verardi, Raffaello, Xu, Kai, Yang, Yongping, Zhang, Baoshan, Chambers, Michael, Changela, Anita, Corrigan, Angela R., Kong, Rui, Olia, Adam S., Ou, Li, Sarfo, Edward K., Wang, Shuishu, Wu, Winston, Doria-Rose, Nicole A., McDermott, Adrian B., Mascola, John R., Kwong, Peter D.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2020
主題:
Vaccines and Antiviral Agents
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7307166/
https://ncbi.nlm.nih.gov/pubmed/32295908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00074-20
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