Development of a 3Mut-Apex-Stabilized Envelope Trimer That Expands HIV-1 Neutralization Breadth When Used To Boost Fusion Peptide-Directed Vaccine-Elicited Responses

HIV-1 envelope (Env) trimers, stabilized in a prefusion-closed conformation, can elicit humoral responses capable of neutralizing HIV-1 strains closely matched in sequence to the immunizing strain. One strategy to increase elicited neutralization breadth involves vaccine priming of immune responses...

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Bibliografski detalji
Izdano u:J Virol
Glavni autori: Chuang, Gwo-Yu, Lai, Yen-Ting, Boyington, Jeffrey C., Cheng, Cheng, Geng, Hui, Narpala, Sandeep, Rawi, Reda, Schmidt, Stephen D., Tsybovsky, Yaroslav, Verardi, Raffaello, Xu, Kai, Yang, Yongping, Zhang, Baoshan, Chambers, Michael, Changela, Anita, Corrigan, Angela R., Kong, Rui, Olia, Adam S., Ou, Li, Sarfo, Edward K., Wang, Shuishu, Wu, Winston, Doria-Rose, Nicole A., McDermott, Adrian B., Mascola, John R., Kwong, Peter D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2020
Teme:
Vaccines and Antiviral Agents
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7307166/
https://ncbi.nlm.nih.gov/pubmed/32295908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00074-20
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