Fusion peptide priming reduces immune responses to HIV-1 envelope trimer base

Soluble “SOSIP”-stabilized envelope (Env) trimers are promising HIV-vaccine immunogens. However, they induce high-titer responses against the glycan-free trimer base, which is occluded on native virions. To delineate the effect on base responses of priming with immunogens targeting the fusion peptid...

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Publicat a:Cell Rep
Autors principals: Corrigan, Angela R., Duan, Hongying, Cheng, Cheng, Gonelli, Christopher A., Ou, Li, Xu, Kai, DeMouth, Megan E., Geng, Hui, Narpala, Sandeep, O’Connell, Sarah, Zhang, Baoshan, Zhou, Tongqing, Basappa, Manjula, Boyington, Jeffrey C., Chen, Steven J., O’Dell, Sijy, Pegu, Amarendra, Stephens, Tyler, Tsybovsky, Yaroslav, van Schooten, Jelle, Todd, John P., Wang, Shuishu, Doria-Rose, Nicole A., Foulds, Kathryn E., Koup, Richard A., McDermott, Adrian B., van Gils, Marit J., Kwong, Peter D., Mascola, John R.
Format: Artigo
Idioma:Inglês
Publicat: 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8070658/
https://ncbi.nlm.nih.gov/pubmed/33826898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108937
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