Fusion peptide priming reduces immune responses to HIV-1 envelope trimer base

Soluble “SOSIP”-stabilized envelope (Env) trimers are promising HIV-vaccine immunogens. However, they induce high-titer responses against the glycan-free trimer base, which is occluded on native virions. To delineate the effect on base responses of priming with immunogens targeting the fusion peptid...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Cell Rep
Κύριοι συγγραφείς: Corrigan, Angela R., Duan, Hongying, Cheng, Cheng, Gonelli, Christopher A., Ou, Li, Xu, Kai, DeMouth, Megan E., Geng, Hui, Narpala, Sandeep, O’Connell, Sarah, Zhang, Baoshan, Zhou, Tongqing, Basappa, Manjula, Boyington, Jeffrey C., Chen, Steven J., O’Dell, Sijy, Pegu, Amarendra, Stephens, Tyler, Tsybovsky, Yaroslav, van Schooten, Jelle, Todd, John P., Wang, Shuishu, Doria-Rose, Nicole A., Foulds, Kathryn E., Koup, Richard A., McDermott, Adrian B., van Gils, Marit J., Kwong, Peter D., Mascola, John R.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2021
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8070658/
https://ncbi.nlm.nih.gov/pubmed/33826898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108937
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