Fusion peptide priming reduces immune responses to HIV-1 envelope trimer base

Soluble “SOSIP”-stabilized envelope (Env) trimers are promising HIV-vaccine immunogens. However, they induce high-titer responses against the glycan-free trimer base, which is occluded on native virions. To delineate the effect on base responses of priming with immunogens targeting the fusion peptid...

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Detaylı Bibliyografya
Yayımlandı:Cell Rep
Asıl Yazarlar: Corrigan, Angela R., Duan, Hongying, Cheng, Cheng, Gonelli, Christopher A., Ou, Li, Xu, Kai, DeMouth, Megan E., Geng, Hui, Narpala, Sandeep, O’Connell, Sarah, Zhang, Baoshan, Zhou, Tongqing, Basappa, Manjula, Boyington, Jeffrey C., Chen, Steven J., O’Dell, Sijy, Pegu, Amarendra, Stephens, Tyler, Tsybovsky, Yaroslav, van Schooten, Jelle, Todd, John P., Wang, Shuishu, Doria-Rose, Nicole A., Foulds, Kathryn E., Koup, Richard A., McDermott, Adrian B., van Gils, Marit J., Kwong, Peter D., Mascola, John R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2021
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8070658/
https://ncbi.nlm.nih.gov/pubmed/33826898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108937
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