MYC protein stability is negatively regulated by BRD4

The protooncogene MYC regulates a variety of cellular processes, including proliferation and metabolism. Maintaining MYC at homeostatic levels is critical to normal cell function; overexpression drives many cancers. MYC stability is regulated through phosphorylation: phosphorylation at Thr58 signals...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Devaiah, Ballachanda N., Mu, Jie, Akman, Ben, Uppal, Sheetal, Weissman, Jocelyn D., Cheng, Dan, Baranello, Laura, Nie, Zuqin, Levens, David, Singer, Dinah S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7306749/
https://ncbi.nlm.nih.gov/pubmed/32482868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1919507117
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