Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition

The intestinal absorption of cholesterol is mediated by a multipass membrane protein, Niemann-Pick C1-Like 1 (NPC1L1), the molecular target of a cholesterol lowering therapy ezetimibe. While ezetimibe gained Food and Drug Administration approval in 2002, its mechanism of action has remained unclear....

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發表在:Sci Adv
Main Authors: Huang, Ching-Shin, Yu, Xinchao, Fordstrom, Preston, Choi, Kaylee, Chung, Ben C., Roh, Soung-Hun, Chiu, Wah, Zhou, Mingyue, Min, Xiaoshan, Wang, Zhulun
格式: Artigo
語言:Inglês
出版: American Association for the Advancement of Science 2020
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Research Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7304964/
https://ncbi.nlm.nih.gov/pubmed/32596471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb1989
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